Dynamics of progesterone, estradiol, cortisol, triiodothyronine and indicators of adaptive immunity concentrations in female dogs during estrus





Estrus, Phagocytic activity of neutrophils, Progesterone, Estradiol, Cortisol


In different periods of postnatal ontogenesis in dogs, as well as in other animals, there are critical physiological periods, the adequacy of which depends on immunoendocrine homeostasis. The estrus in bitches is a critical period because it lasts longer than in other mammals and has specific endocrine and immune changes in the body. In this study authors demonstrated the dynamics of changes in hormone content and indicators of adaptive cellular immunity in bitches during the estrus. Determination of these indicators does not require expensive laboratory equipment and is available in veterinary practice. Taking into account the fact that estrus in dogs lasts long enough, it is not clear enough what indicators and in what terms should be determined for predicting possible dysfunctions of the reproductive system and, as a result, premature impossibility of reproduction in bitches. The peak concentration of progesterone occurs on the 20th day of estrus, the reaction of the immune system, which is manifested by the maximum decrease in the phagocytic activity of neutrophils, should be noted. An increase in the concentration of estradiol on the 5th day of estrus, in contrast to progesterone, had the opposite effect on phagocytic activity of neutrophils, namely, the ability of neutrophils to phagocytosis increased. Further, we conducted clinical animals’ observations for three months after estrus for the possibility of inflammatory processes in the reproductive system development. According to the obtained indicators, no complications were found.


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